苏大附一院

院内学术讲座
部门:    作者:     发布时间:2018-07-10    浏览:4705次
 

讲座题目:Control of Tumor Growth, Microenviroment and Metabolism by Cell Adhesion-Lined Pathways

主 讲 人:Dr. Xiuwei Yang, Assistant Professor

          Department of Pharmacology & Nutritional Sciences, University of Kentucky

讲座时间:2018710日(星期二)下午13: 30

讲座地点:苏州大学附属第一医院(总院)12楼呼吸内科示教室

Dr. Yang 简历

杨教授现任美国肯塔基大学助理教授(Tenure Track),加拿大Manitoba大学博士、美国哈佛大学Dana-Farber肿瘤研究所博士后。美国癌症研究协会会员、美国细胞生物学会会员。主要从事以乳腺癌为主的多种实体瘤细胞与分子生物学研究,尤其在肿瘤转移相关表面蛋白的相互作用机制方面取得了突出的成绩。首次在国际上提出了跨膜四蛋白家族成员CD151通过调控整合素α3β1α6β1α6β4,进而起到对乳腺癌发生、发展产生影响。近年来,杨教授主持承担总额100万美金的各类课题;以通讯作者等身份在《Oncogenesis》、Cell Cycle》、J Cell Sci》、Cancer Res》、J Cell Biol》、《Oncogene》、《Neoplasia》和《J Biol Chem》等国际权威期刊上发表论文20余篇。此外、杨教授还担任包括Intl J CancerPlos One等多种国际学术期刊的审稿人。

代表性论文

1.         Bingwei Xu, Jason Lefringhouse, Zeyi Liu, et.al. Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy. Oncogenesis. 2017 Jan 30;6(1):e295.

2.         Yin Y, Deng X, Liu Z, et.al.. CD151 represses mammary gland development by maintaining the niches of progenitor cells. Cell Cycle. 2014;13(17):2707-22.

3.         Zhou P, Erfani S, Liu Z, et.al. CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. Oncotarget. 2015 Oct 6;6(30):29675-93.

4.         Baldwin LA, Hoff JT, Lefringhouse J, et.al. CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling. Oncotarget. 2014 Dec 15;5(23):12203-17.

5.         Yang X*, Mirchev R, Deng X, Yacono P, Yang HL, Golan DE, Hemler ME. CD151 restricts the a6 integrin diffusion mode. J Cell Sci 2012, 125:1478-87.

6.         Deng X, Li Q, Hoff JT, Novak M. Yang, HL, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Yi A, Zhou P, Stipp CS, Kaetzel DM, Hemler ME and Yang X*. Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia 2012, 14:678-689.

7.         Yang X, Flores L, Li Q, Zhou P, Xu F, Krop IE, and Hemler ME. Disruption OF Laminin-Integrin-CD151-FAK Axis Sensitizes Breast cancer Cells to ErbB2 Antagonists. Cancer Res 2010, 70:2256-2263.  

8.         Yang X*, Richardson AL, Torres-Arzayus M, Zhou P, Sharma C, Andzelm MM, Strongminger JA, Brown M and Hemler ME. CD151 accelerates breast cancer progression by regulating a6 integrin function, signaling, and molecular organization. Cancer Res 2008, 68:3204-3213.